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KMID : 0365819710110020147
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Journal of Pusan Medical College
1971 Volume.11 No. 2 p.147 ~ p.154
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Effects of Circulatory Disturbance of the liver on Plasma Iron Concentration in Rabbits
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Abstract
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The author intended to investigate the effect of liver damage produced by ligation of the hepatic artery or narrowing the portal vein. In this study rabbits were used as experimental animals. Change in plasma iron concentration was observed following ligation of the hepatic artery or stricture of the portal vein in normal rabbits and following parenteral iron administration or removal of blood in rabbits with ligated hepatic artery or with strictured portal vein. The results thus obtained were discussed and the following conclusions were drawn.
1.. The plasma iron concentration increased in the early time and then decreased in the late time following ligation of the hepatic artery or stricture of the portal vein in normal rabbits. This biphasic change in plasma iron concentration was more marked in the rabbits with ligated hepatic artery than in the rabbits with strictured portal vein.
2. Following intravenous iron administration, the plasma iron concentration increased in the rabbits with ligated hepatic artery or with strictured portal vein and in intact rabbits. The degree of rise in plasma iron concentration was in the order of the intact rabbits, the rabbits with strictured portal vein and the rabbits with ligated hepatic artery.
3. Following the removal of blood, the plasma iron concentration decreased in the early time and then returned to normal in the intact rabbits and in the rabbits with strictured portal vein, but it decreased continuously in the rabbits with ligated hepatic artery.
On the basis of the above it is suggested that the change in plasma iron concentration in liver damage depends upon the stage and severity of the injurious process.
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